5 AMINO-1

Metabolic Optimization | Fat Loss | Cellular Longevity

5-Amino-1MQ

For Research Use Only. Not for Human or Veterinary Consumption.

5-Amino-1MQ is a synthetic small molecule inhibitor studied for its ability to modulate nicotinamide N-methyltransferase (NNMT) activity in cellular models. It is commonly used in laboratory research to explore metabolic regulation, cellular energy balance, and epigenetic influences on metabolic pathways. Researchers investigate 5-Amino-1MQ to better understand its role in modulating metabolic enzyme function within experimental systems.

This product is provided exclusively for qualified laboratory research. Not intended for therapeutic, diagnostic, or human use.

Mechanism of Action

5-Amino-1MQ works by selectively inhibiting NNMT, an enzyme overexpressed in white adipose tissue, liver, and various cancers. Elevated NNMT is associated with:

• Lower NAD+ levels (critical for mitochondrial energy)
• Reduced fat oxidation
• Poor metabolic flexibility 

By blocking NNMT, 5-Amino-1MQ allows higher NAD+ concentrations inside cells, which in turn enhances:

• Mitochondrial energy production (ATP)
• Lipolysis and fat mobilization
• Glucose utilization and insulin sensitivity

It is considered synergistic when used alongside NAD+ boosters, GLP-1 agonists (like Retatrutide or Semaglutide), and mitochondrial peptides like MOTS-c.